Acetic Acid → N-(3-n-Butylamino-4-phenoxy-5-sulfamylbenzyl)acetamide

HRID 1390074노트

반응식

HRID 1390074 반응식
[CH2:1]([NH:5][C:6]1[CH:7]=[C:8]([CH:11]=[C:12]([S:21](=[O:24])(=[O:23])[NH2:22])[C:13]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:9][NH2:10])[CH2:2][CH2:3][CH3:4].[C:25](O)(=[O:27])[CH3:26]>C(OC(=O)C)(=O)C>[CH2:1]([NH:5][C:6]1[CH:7]=[C:8]([CH:11]=[C:12]([S:21](=[O:24])(=[O:23])[NH2:22])[C:13]=1[O:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[CH2:9][NH:10][C:25](=[O:27])[CH3:26])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 540392965-(Aminomethyl)-3-(butylamino)-2-phenoxybenzene-1-sulfonamide

생성물 1

HCID 53985487N-(3-n-Butylamino-4-phenoxy-5-sulfamylbenzyl)acetamide

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

실험 절차

To a solution of 3-n-butylamino-4-phenoxy-5-sulfamylbenzylamine (1.05 g; prepared as described in Example 289) in acetic acid (10 ml), acetic anhydride (0.4 ml) is added and the mixture is left for 24 hours. Dilution with water (25 ml) precipitates N-(3-n-butylamino-4-phenoxy-5-sulfamylbenzyl)acetamide, which is collected by filtration, washed with water and dried in air. After recrystallization from aqueous ethanol it is obtained with a melting point of 190°-191° C.

후처리

  1. customDilution with water (25 ml) precipitates N-(3-n-butylamino-4-phenoxy-5-sulfamylbenzyl)acetamide, which
  2. filtrationis collected by filtration
  3. washwashed with water
  4. customdried in air
  5. customAfter recrystallization from aqueous ethanol it
  6. customis obtained with a melting point of 190°-191° C.

출처 및 근거

ORD 기록
ord-c230f020fef742a2b9c9b5abd06a11c8
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04247550

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