홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

4-Methylmorpholine → Boc-(D)-Ala-Gly-MePhe-Leu-OMe

HRID 1390157
노트
인쇄 미리보기

반응식

HRID 1390157 반응식
[NH:1]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[C@@H:2]([C:4]([NH:6][CH2:7][C:8]([OH:10])=O)=[O:5])[CH3:3].CN1CCOCC1.C(OC(Cl)=O)C(C)C.[NH:33]([CH3:54])[C@H:34]([C:42]([NH:44][C@H:45]([C:50]([O:52][CH3:53])=[O:51])[CH2:46][CH:47]([CH3:49])[CH3:48])=[O:43])[CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1.C(N(C)[C@H](C(N[C@H](C(OC)=O)CC(C)C)=O)CC1C=CC=CC=1)(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O.C(Cl)Cl>C1COCC1.CN(C=O)C>[NH:1]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[C@@H:2]([C:4]([NH:6][CH2:7][C:8]([N:33]([CH3:54])[C@H:34]([C:42]([NH:44][C@H:45]([C:50]([O:52][CH3:53])=[O:51])[CH2:46][CH:47]([CH3:49])[CH3:48])=[O:43])[CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:10])=[O:5])[CH3:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

9

반응물 6

HCID 79724-Methylmorpholine2회HCID 62365Isobutyl chloroformateHCID 12944592(N-Boc-D-alanyl)-glycineHCID 13918317Boc-MePhe-Leu-OMeHCID 13945171H-MePhe-Leu-OMeHCID 21863450Trifluoroacetic acid methylene chloride

생성물 1

HCID 131712075
Boc-(D)-Ala-Gly-MePhe-Leu-OMe

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 24.6 g of Boc-(D)-Ala-Gly-OH and 11.2 ml of N-methylmorpholine in 400 ml of THF are added 13.2 ml of chloroformic acid isobutyl ester at -25°. After 5 minutes, at 25°, 11.2 ml of N-methyl-morpholine and 42.1 g of H-MePhe-Leu-OMe (trifluoroacetate) in DMF [which has previously been prepared by the treatment of Boc-MePhe-Leu-OMe with TFA-methylene chloride (1:1)] are added. After 2 hours, at -15°, the title compound is isolated as described under (a) above, as a solid foam.

후처리

  1. additionare added
  2. waitAfter 2 hours

출처 및 근거

ORD 기록
ord-5407d542daed4a63b994859e86ba853c
출처 데이터셋
uspto-grants-1981_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04247543

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트