Acetic Acid → 2-(Benzylamino)-2-methylpropan-1-ol

HRID 1390658

반응식

HRID 1390658 반응식
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:9][C:10]([CH3:14])([CH3:13])[CH2:11][OH:12].C(O)(=O)C.C1C=CC=CC=1>O>[CH2:1]([NH:9][C:10]([CH3:14])([CH3:13])[CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 240BenzaldehydeHCID 241BenzeneHCID 118072-Amino-2-methyl-1-propanol

생성물 1

HCID 9623682-(Benzylamino)-2-methylpropan-1-ol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 106 g of benzaldehyde, 89 g of 2-amino-2-methyl-1-propanol, 2 ml of glacial acetic acid and 500 ml of benzene is heated for 3 hours under reflux, using a water separator. After completion of the reaction, the mixture is evaporated and the residue is dissolved in 2 liters of ethanol. After adding a total of 76 g of sodium borohydride in portions over the course of 2-3 hours, continuing to stir the mixture overnight at room temperature, and working up in the usual manner, 2-benzylamino-2-methyl-1-propanol is obtained, which melts at 50°-55° C. after crystallisation from ether.

후처리

  1. temperatureis heated for 3 hours
  2. temperatureunder reflux
  3. customAfter completion of the reaction
  4. customthe mixture is evaporated
  5. dissolutionthe residue is dissolved in 2 liters of ethanol
  6. additionAfter adding a total of 76 g of sodium borohydride in portions over the course of 2-3 hours

출처 및 근거

ORD 기록
ord-d6c9a2e954ef4d2dafe3b91d854c2d33
출처 데이터셋
uspto-grants-1979_02
특허 번호
US04139623

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