Acetic Acid → [4-(2-Bromoethyl)phenyl]acetic acid

HRID 1391183노트

반응식

HRID 1391183 반응식
[Br:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7](CC#N)=[CH:6][CH:5]=1.[C:13]([OH:16])(=[O:15])[CH3:14]>Br>[Br:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:14][C:13]([OH:16])=[O:15])=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 20386067HCID 20386067, 화합물

생성물 1

HCID 20386065[4-(2-Bromoethyl)phenyl]acetic acid

시약·촉매·용매 1

HCID 260Hydrogen Bromide용매

실험 절차

A solution of [4-(2-bromoethyl)phenyl]acetonitrile (56.0 g., 0.25 mole) in 48% hydrobromic acid (200 ml.) and acetic acid (600 ml.) is boiled under reflux for 4 hours. The solution is reduced to one-third volume by distillation at reduced pressure. The residue is diluted with 400 ml. of water to force out the oily product which is taken up in ether, washed with water, and dried over sodium sulfate. Evaporation of the solvent leaves the title compound as a residual oil.

후처리

  1. temperatureunder reflux for 4 hours
  2. distillationThe solution is reduced to one-third volume by distillation at reduced pressure
  3. additionThe residue is diluted with 400 ml
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-0ba67f43bb54494f822f54116dafa631
출처 데이터셋
uspto-grants-1979_02
특허 번호
US04140861

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