Sodium Hydroxide → 1-methyl-5-nitro-1H-benzimidazol-2-amine

HRID 1391547노트

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HRID 1391547 반응식
[CH3:1][NH:2][C:3]1[C:4]([NH2:12])=[CH:5][C:6]([N+:9]([O-:11])=[O:10])=[CH:7][CH:8]=1.[N-:13]=[C:14]=S.[Br-].[OH-].[Na+]>CO>[CH3:1][N:2]1[C:3]2[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:4]=2[N:12]=[C:14]1[NH2:13]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 34200251-N-methyl-4-nitrobenzene-1,2-diamineHCID 178419725HCID 178419725, 화합물

생성물 1

HCID 450786361-methyl-5-nitro-1H-benzimidazol-2-amine

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of N1-Methyl-4-nitro-benzene-1,2-diamine (5 g, 30 mmol) in MeOH was added bromide isothiocyanate (4.4 g, 42 mmol) and the mixture was stirred at rt. After 16 h. 6N NaOH solution was added to the reaction mixture until Ph˜10 and MeOH was then removed in vacuo. H2O was added and the solid was filtered and dried to give the title compound as an off white solid (5.2 g, 90%). MS (ESI) m/z=193 [M+H]+.

후처리

  1. customwas then removed in vacuo
  2. additionH2O was added
  3. filtrationthe solid was filtered
  4. customdried

출처 및 근거

ORD 기록
ord-b2b71a75ab654a4c9e9d2aba2c7a4fee
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07338959B2

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