1-(6-Bromo-2-pyridinyl)-1-pentanol → 1-(6-Bromopyridin-2-yl)pentan-1-one

HRID 1391774

반응식

HRID 1391774 반응식
[Br:1][C:2]1[N:7]=[C:6]([CH:8]([OH:13])[CH2:9][CH2:10][CH2:11][CH3:12])[CH:5]=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.[O-2].[Mn+2]>[Br:1][C:2]1[N:7]=[C:6]([C:8](=[O:13])[CH2:9][CH2:10][CH2:11][CH3:12])[CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 586299071-(6-Bromo-2-pyridinyl)-1-pentanol

생성물 1

HCID 586298071-(6-Bromopyridin-2-yl)pentan-1-one수율 62.2%

시약·촉매·용매 2

HCID 160959Manganese oxide촉매HCID 6212Chloroform용매

실험 절차

To a stirring solution of 1-(6-bromo-2-pyridinyl)-1-pentanol (1.01 g, 4.15 mmol) in chloroform (27 mL) was added manganese oxide (14.24 g, 0.16 mol) portion-wise over 4 h. The mixture was then left to stir for an additional 3.5 h and was then filtered through celite placed directly on the top of a SPE (silica, 20 g cartridge) eluting with chloroform. The filtrate was reduce under vacuum and then purified further by SPE (silica, 20 g cartridge) eluting with cyclohexane:EtOAc (gradient 100:1 to 5:1) afforded the title compound as an oil (625 mg).

후처리

  1. waitThe mixture was then left
  2. filtrationwas then filtered through celite
  3. washeluting with chloroform
  4. custompurified further by SPE (silica, 20 g cartridge)
  5. washeluting with cyclohexane

출처 및 근거

ORD 기록
ord-4b6bb5c3f566461f9d013386517b42cf
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07338960B2

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