Diazomethane → (+)-Methyl 2-(4-bromo-2-fluorophenyl)cyclopropanecarboxylate

HRID 1392720노트

반응식

HRID 1392720 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:10][CH:9]2[C:11]([OH:13])=[O:12])=[C:4]([F:14])[CH:3]=1.[N+](=[CH2:17])=[N-]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:10][CH:9]2[C:11]([O:13][CH3:17])=[O:12])=[C:4]([F:14])[CH:3]=1

참가 물질

4

반응물 2

HCID 9550DiazomethaneHCID 438103082-(4-Bromo-2-fluorophenyl)cyclopropane-1-carboxylic acid

생성물 1

HCID 69157593(+)-Methyl 2-(4-bromo-2-fluorophenyl)cyclopropanecarboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (+)-2-(4-bromo-2-fluorophenyl)cyclopropanecarboxylic acid from step 7 (1 eq) in methylenechloride was added an ethereal solution of diazomethane until reaction is completed by TLC. The resulting mixture was concentrated. The crude ester was used as such in the next step.

후처리

  1. customuntil reaction
  2. concentrationThe resulting mixture was concentrated

출처 및 근거

ORD 기록
ord-5d3832655d794ff1aff3fa74ae65fa4c
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07342024B2

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