Acetone → 3-(Benzylamino)-3-methylbutanoic Acid
반응식
[CH3:1][C:2]([CH3:7])=[CH:3][C:4]([OH:6])=[O:5].[CH2:8]([NH2:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CC(C)=O>N1C=CC=CC=1>[CH2:8]([NH:15][C:2]([CH3:7])([CH3:1])[CH2:3][C:4]([OH:6])=[O:5])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1참가 물질
5
반응 조건
- 온도
- 120 °C
실험 절차
3-Methylcrotonic acid (12.0 g) was dissolved in pyridine (40 ml), and benzyl amine (12.8 g) was added thereto, and the mixture was stirred for 3 hours at 120° C. The reaction mixture was cooled to room temperature, and after acetone was added to the resulting suspension, crystals were collected by filtration and washed. The crystals were dried under reduced pressure to give 3-benzylamino-3-methylbutanoic acid (10.3 g, Y.:42%) as colorless crystals.
후처리
- temperatureThe reaction mixture was cooled to room temperature
- filtrationwere collected by filtration
- washwashed
- customThe crystals were dried under reduced pressure
출처 및 근거
- ORD 기록
- ord-a65ca87bd6824b3a80fcd4887b697153
- 출처 데이터셋
- uspto-grants-2008_03
- 특허 번호
- US07345180B2
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