Hydrochloric Acid → 2-{4-[(3,7-Dimethyl-2,6-octadienyl)oxy]phenyl}acetic acid

HRID 1393849노트

반응식

HRID 1393849 반응식
[OH-].[K+].[CH3:3][C:4]([CH2:19][CH2:20][CH:21]=[C:22]([CH3:24])[CH3:23])=[CH:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15]([O:17]C)=[O:16])=[CH:10][CH:9]=1.Cl>CO>[CH3:3][C:4]([CH2:19][CH2:20][CH:21]=[C:22]([CH3:24])[CH3:23])=[CH:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15]([OH:17])=[O:16])=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 69306599Methyl 2-{4-[(3,7-dimethyl-2,6-octadienyl)oxy]phenyl}acetate

생성물 1

HCID 545318442-{4-[(3,7-Dimethyl-2,6-octadienyl)oxy]phenyl}acetic acid수율 61%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1N potassium hydroxide (46 ml) was added to a solution of methyl 2-{4-[(3,7-dimethy-2,6-octadienyl)oxy]phenyl}acetate (9.46 g, 31.28 mmol) in methanol (70 ml) and refluxed for 1 hour. The mixture, with 3N hydrochloric acid (50 ml) added thereto, was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over MgSO4, and then concentrated. The residue was purified by recrystallization (ethyl acetate/hexane), to give 2-{4-[(3,7-dimethyl-2,6-octadienyl)oxy]phenyl}acetic acid (5.50 g, 61%).

후처리

  1. temperaturerefluxed for 1 hour
  2. extractionwas extracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated
  6. customThe residue was purified by recrystallization (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-12646011c54340569cd697ee92dfad55
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07348017B2

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