홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → 2-(2-1H-Indol-3-ylacetylamino)-4-methylpentanoic acid (4-dimethylamino-4-phenylcyclohexyl)amide hydrochloride

HRID 1394249
노트
인쇄 미리보기

반응식

HRID 1394249 반응식
Cl.[CH3:2][N:3]([CH3:37])[C:4]1([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:30])[CH:12]([NH:17][C:18](=[O:29])[CH2:19][C:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][CH:21]=2)[CH2:13][CH:14]([CH3:16])[CH3:15])[CH2:6][CH2:5]1.C[Si](C)(C)[Cl:40]>CC(CC)=O>[ClH:40].[CH3:37][N:3]([CH3:2])[C:4]1([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:30])[CH:12]([NH:17][C:18](=[O:29])[CH2:19][C:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][CH:21]=2)[CH2:13][CH:14]([CH3:15])[CH3:16])[CH2:6][CH2:5]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6397ChlorotrimethylsilaneHCID 98282222-(2-1H-Indol-3-ylacetylamino)-4-methylpentanoic acid (4-dimethylamino-4-phenylcyclohexyl)amide

생성물 1

HCID 98282212-(2-1H-Indol-3-ylacetylamino)-4-methylpentanoic acid (4-dimethylamino-4-phenylcyclohexyl)amide hydrochloride

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone
용매

실험 절차

In order to produce the hydrochloride (Example 16), the more polar compound of 2-(2-1H-indol-3-ylacetylamino)-4-methylpentanoic acid-(4-dimethylamino-4-phenylcyclohexyl)amide (320 mg, 0.66 mmole) was dissolved in ethyl methyl ketone and combined with trimethylchlorosilane (125 μl, 0.99 mmole). The resulting solid was filtered out and dried. Example 16 was obtained as a colorless solid (m.p. 174-176° C.) in a yield of 170 mg (50%).

후처리

  1. filtrationThe resulting solid was filtered out
  2. customdried

출처 및 근거

ORD 기록
ord-f1167491b1b04f2f8f11cd2590a68f0d
출처 데이터셋
uspto-grants-2008_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07348354B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트