Hydrochloric Acid → 4-[(4-Fluorophenyl)methyl]piperidine hydrochloride

HRID 1394293노트

반응식

HRID 1394293 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[F:21][C:18]1[CH:17]=[CH:16][C:15]([CH2:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:20][CH:19]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 226766794-(4-Fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 170394924-[(4-Fluorophenyl)methyl]piperidine hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To 1-tert-butoxycarbonyl-4-(4-fluorobenzyl)piperidine (39.9 g) was added 4N-hydrogen chloride in ethyl acetate (100 ml), and the solution was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure, and to the concentrate was added diethyl ether. The resulting precipitates were collected by filtration, washed with diethyl ether, and dried under reduced pressure to give the titled compound (30.1 g).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionto the concentrate was added diethyl ether
  3. customThe resulting precipitates
  4. filtrationwere collected by filtration
  5. washwashed with diethyl ether
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-3b2221855024433592a4772758a93c93
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07348324B2

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