반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][CH2:12][CH:13]([OH:26])[CH2:14][C:15]2[C:16](O)=[C:17]3[C:21](=[CH:22][C:23]=2[Cl:24])[CH2:20][CH2:19][CH2:18]3)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([O:11][CH2:12][CH:13]2[O:26][C:16]3[C:17]4[CH2:18][CH2:19][CH2:20][C:21]=4[CH:22]=[C:23]([Cl:24])[C:15]=3[CH2:14]2)(=[O:9])=[O:10])=[CH:6][CH:7]=1참가 물질
4
실험 절차
Treatment of (±)-3-(6-chloro-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-hydroxypropyl 4-methylbenzenesulfonate (4.7 g, 0.012 mol) with triphenylphosphine (4.64 g, 0.018 mol) and diisopropylazodicarboxylate (3.57 g, 0.018 mol) generally according to the procedure described for Intermediate 5 gave 4.09 g (91%) of (±)-(4-chloro-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan-2-yl)methyl 4-methylbenzenesulfonate as a white solid. mp 95-97° C.; Anal. calcd. for C19H19ClO4S: C, 60.23; H, 5.05. Found: C, 60.12; H, 4.97.
출처 및 근거
- ORD 기록
- ord-714700fe06cf405db662baa55aff6c87
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07728155B2
연결된 노트
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