Hydrazine → (Adamant-1-ylmethyl)hydrazine hydrochloride

HRID 1395183

반응식

HRID 1395183 반응식
[NH2:1][NH2:2].[Cl:3][CH2:4][C:5]12[CH2:14][CH:9]3[CH2:10][CH:11]([CH2:13][CH:7]([CH2:8]3)[CH2:6]1)[CH2:12]2.[OH-].[Na+]>CO.O>[ClH:3].[C:5]12([CH2:4][NH:1][NH2:2])[CH2:14][CH:9]3[CH2:10][CH:11]([CH2:13][CH:7]([CH2:8]3)[CH2:6]1)[CH2:12]2

참가 물질

6

반응물 3

HCID 9321HydrazineHCID 14798Sodium HydroxideHCID 21039691-(Chloromethyl)adamantane

생성물 1

HCID 20340449(Adamant-1-ylmethyl)hydrazine hydrochloride수율 38.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

4.0 g (120 mmol) of anhydrous hydrazine and 2.3 g (12 mmol) of 1-chloromethyladamantane were introduced into a sealable tube under nitrogen atmosphere. The tube was sealed and heated at 150° for 16 hours. After cooling to room temperature the contents were suspended in methanol, treated with a solution 0.5 g of sodium hydroxide in 1.5 ml of water, and the volatiles removed in vacuo. The resulting solid was extracted with ether and the solution dried with magnesium sulfate and treated with hydrogen chloride to give 1 g of the title compound (38% yield).

후처리

  1. customThe tube was sealed
  2. temperatureheated at 150° for 16 hours
  3. customthe volatiles removed in vacuo
  4. extractionThe resulting solid was extracted with ether
  5. dry with materialthe solution dried with magnesium sulfate
  6. additiontreated with hydrogen chloride

출처 및 근거

ORD 기록
ord-d19c0c7c64f745719d8f55933f50ae2d
출처 데이터셋
uspto-grants-1980_05
특허 번호
US04202892

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