Hydrogen Peroxide → 1-[3-(p-Tert.amyl-phenyl)-2-methyl-propyl]-piperidine-1-oxide

HRID 1395210노트

반응식

HRID 1395210 반응식
[OH:1]O.[C:3]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH:15]([CH3:23])[CH2:16][N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:10][CH:9]=1)([CH2:6][CH3:7])([CH3:5])[CH3:4]>C(O)(C)C.[Pt]>[C:3]([C:8]1[CH:9]=[CH:10][C:11]([CH2:14][CH:15]([CH3:23])[CH2:16][N+:17]2([O-:1])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)=[CH:12][CH:13]=1)([CH2:6][CH3:7])([CH3:4])[CH3:5]

참가 물질

5

반응물 2

HCID 784Hydrogen Peroxide2회HCID 190989441-[3-(p-Tert.amyl-phenyl)-2-methyl-propyl]-piperidine

생성물 1

HCID 203405661-[3-(p-Tert.amyl-phenyl)-2-methyl-propyl]-piperidine-1-oxide

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 3776Isopropanol용매

반응 조건

온도
40 °C

실험 절차

7.2 g of 30% hydrogen peroxide are added dropwise at 40° C. to a solution of 5.8 g of 1-[3-(p-tert.amyl-phenyl)-2-methyl-propyl]-piperidine in 20 ml of isopropanol and this addition is repeated after 24 hours. After stirring at 40° C. for 60 hours, the mixture is cooled and the excess hydrogen peroxide is decomposed by addition of platinum sponge. The solution is filtered, the filtrate is evaporated, the residue is taken up in 50 ml of water and extracted with hexane. The aqueous solution is subsequently evaporated and the residue is dried in a high vacuum. There is obtained pure 1-[3-(p-tert.amyl-phenyl)-2-methyl-propyl]-piperidine-1-oxide; nD20 =1.5180.

후처리

  1. additionthis addition
  2. temperaturethe mixture is cooled
  3. filtrationThe solution is filtered
  4. customthe filtrate is evaporated
  5. extractionextracted with hexane
  6. customThe aqueous solution is subsequently evaporated
  7. customthe residue is dried in a high vacuum

출처 및 근거

ORD 기록
ord-5ff15de35f5145cc8cea553fe2009f56
출처 데이터셋
uspto-grants-1980_05
특허 번호
US04202894

반응 노트

불러오는 중…