Ammonia → HCID 479082, 화합물
반응식
C([NH:4][C:5]1[C:10]([CH2:11][C:12]2[CH:21]=[C:20]([O:22][CH3:23])[C:15]([C:16](O)([CH3:18])[CH3:17])=[C:14]([O:24][CH3:25])[CH:13]=2)=[CH:9][N:8]=[C:7]([NH2:26])[N:6]=1)(=O)C.Cl.N>>[NH2:26][C:7]1[N:6]=[C:5]([NH2:4])[C:10]([CH2:11][C:12]2[CH:13]=[C:14]([O:24][CH3:25])[C:15]([C:16]([CH3:18])=[CH2:17])=[C:20]([O:22][CH3:23])[CH:21]=2)=[CH:9][N:8]=1참가 물질
4
실험 절차
A solution of 5.0 mg. of 4-[(4-acetylamino-2-amino-5-pyrimidyl)-methyl]-2,6-dimethoxy-α,α-dimethylbenzyl alcohol was warmed under reflux for 1 hour in 1 ml. of concentrated hydrochloric acid. After cooling, the mixture was adjusted to pH 10 with concentrated aqueous ammonia and extracted three times with 2 ml. of ethyl acetate each time. The extract was dried and evaporated. The residue yielded, after recrystallization from methanol, 3.2 mg. of 2,4-diamino-5-(4-isopropenyl-3,5-dimethoxybenzyl)-pyrimidine, having a melting point of 228°-229° C.
후처리
- temperatureunder reflux for 1 hour in 1 ml
- temperature