Methanol → 2,3,4,4a-Tetrahydro-3-[2-(2-Pyridinyl)Ethyl]-1H-Pyrazino[1,2-a]Quinoxalin-5(6H)-One

HRID 1395445노트

반응식

HRID 1395445 반응식
[CH2:1]1[N:6]2[C:7]3[C:12]([NH:13][C:14](=[O:15])[CH:5]2[CH2:4][NH:3][CH2:2]1)=[CH:11][CH:10]=[CH:9][CH:8]=3.[CH:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)=[CH2:17].CO>C(O)(=O)C>[N:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[CH2:16][CH2:17][N:3]1[CH2:2][CH2:1][N:6]2[C:7]3[C:12]([NH:13][C:14](=[O:15])[CH:5]2[CH2:4]1)=[CH:11][CH:10]=[CH:9][CH:8]=3

참가 물질

5

반응물 3

HCID 887MethanolHCID 75212-VinylpyridineHCID 1563622,3,4,4a-Tetrahydro-1H-pyrazino(1,2a)quinoxalin-5-(6H)one

생성물 1

HCID 203394222,3,4,4a-Tetrahydro-3-[2-(2-Pyridinyl)Ethyl]-1H-Pyrazino[1,2-a]Quinoxalin-5(6H)-One

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one (7 g.) and 2-vinylpyridine (12 g.) in 150 ml. of methanol containing 5 ml. glacial acetic acid were heated under reflux for 24 hours. After removing solvent under reduced pressure, the residue was slurried with water and the insoluble material filtered off and washed with water. After drying there was obtained 9.3 g. of the title compound. A portion recrystallized from ethanol gave a m.p. of 167°-69° C.

후처리

  1. temperatureunder reflux for 24 hours
  2. customAfter removing solvent under reduced pressure
  3. filtrationthe insoluble material filtered off
  4. washwashed with water
  5. customAfter drying there
  6. customwas obtained 9.3 g

출처 및 근거

ORD 기록
ord-a4c4040b93bf44aabe58085acaa7951e
출처 데이터셋
uspto-grants-1980_05
특허 번호
US04203987

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