Hydrochloric Acid → HCID 20339409, 화합물

반응식

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:27][CH2:26][N:12]2[C:13]3[C:18]([NH:19][C:20](=[O:21])[CH:11]2[CH2:10]1)=[CH:17][C:16]([C:22]([F:25])([F:24])[F:23])=[CH:15][CH:14]=3.C(O)C.Cl>[Pt]=O.O>[F:25][C:22]([F:23])([F:24])[C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[N:12]1[CH2:26][CH2:27][N:9]([CH2:8][CH2:7][CH:2]3[CH2:3][CH2:4][CH2:5][CH2:6][NH:1]3)[CH2:10][CH:11]1[C:20](=[O:21])[NH:19]2

참가 물질

실험 절차

A mixture of 5 g. (0.014 mole) of 2,3,4,4a-tetrahydro-3-[2-(2-pyridinyl)ethyl]-8-(trifluoromethyl)-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one, 60 ml. of ethanol, 120 ml. of water, 12 ml. of concentrated hydrogen chloride and 1 g. of platinum oxide catalyst is hydrogenated in a Parr apparatus for 2 hours. The catalyst is filtered and the solvents removed. The residue was crystallized from ethanol and recrystallized from methanol to yield 4.5 g. of the title compound as the dihydrochloride salt, m.p. 283°-286° C. (dec.).