N-(2-Dimethylaminoethyl)-N-(5-methyl-2-pyridyl)acetamide → 2-(2-Dimethylaminoethylamino)-5-methylpyridine

HRID 1395524노트

반응식

HRID 1395524 반응식
[CH3:1][N:2]([CH3:16])[CH2:3][CH2:4][N:5]([C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][N:10]=1)C(=O)C>[OH-].[Na+]>[CH3:1][N:2]([CH3:16])[CH2:3][CH2:4][NH:5][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][N:10]=1

참가 물질

3

반응물 1

HCID 20339535N-(2-Dimethylaminoethyl)-N-(5-methyl-2-pyridyl)acetamide

생성물 1

HCID 203395792-(2-Dimethylaminoethylamino)-5-methylpyridine

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

To N-(2-dimethylaminoethyl)-N-(5-methyl-2-pyridyl) acetamide (50.0 g, 0.226 mole) is added 200 ml of 5 N sodium hydroxide. The mixture is stirred rapidly at reflux for 16 hours. The mixture is cooled and the oil is extracted into ether. The ether extract is dried and evaporated under reduced pressure. Distillation of the residue gives a pale yellow liquid, b.p. 105°-112°, n25D 1.5355. Weight obtained is 35 g.

후처리

  1. temperatureat reflux for 16 hours
  2. temperatureThe mixture is cooled
  3. extractionthe oil is extracted into ether
  4. extractionThe ether extract
  5. customis dried
  6. customevaporated under reduced pressure
  7. distillationDistillation of the residue
  8. customgives a pale yellow liquid, b.p. 105°-112°, n25D 1.5355
  9. customWeight obtained

출처 및 근거

ORD 기록
ord-1718d04284554ea89fa4944c7c42e1c9
출처 데이터셋
uspto-grants-1980_05
특허 번호
US04203988

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