Formic Acid → 3-Nitro-4-formamidobenzaldehyde

HRID 1395564

반응식

HRID 1395564 반응식
[CH:1]([OH:3])=O.[N+:4]([C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=1[NH2:15])[CH:10]=[O:11])([O-:6])=[O:5].C(OC(=O)C)(=O)C>O>[N+:4]([C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=1[NH:15][CH:1]=[O:3])[CH:10]=[O:11])([O-:6])=[O:5]

참가 물질

5

반응물 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 132377034-Amino-3-nitrobenzaldehyde

생성물 1

HCID 203400463-Nitro-4-formamidobenzaldehyde수율 80%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 56.6 ml (1.50 mol) of HCOOH was added 24.9 g (150 mmol) of 3-nitro-4-aminobenzaldehyde. The solution was heated to reflux, 28.4 ml (300 mmol) of acetic anhydride was added dropwise and the solution was refluxed for 30 minutes. The resulting suspension was cooled and poured into 400 ml of cold H2O with rapid stirring. The product was filtered, air dried, and recrystallized from isopropanol to yield 23.2 g (80%) of 3-nitro-4-formamidobenzaldehyde as a bright yellow powder: melting point=183°-191°.

후처리

  1. temperatureThe solution was heated
  2. temperatureto reflux
  3. temperaturethe solution was refluxed for 30 minutes
  4. temperatureThe resulting suspension was cooled
  5. filtrationThe product was filtered
  6. customair dried
  7. customrecrystallized from isopropanol

출처 및 근거

ORD 기록
ord-5031d5b89010401baaa69e62662dd643
출처 데이터셋
uspto-grants-1980_05
특허 번호
US04204069

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