Hydrochloric Acid → HCID 178501377, 화합물

HRID 1395812노트

반응식

HRID 1395812 반응식
[CH3:1][O:2][C:3](=[O:42])[C@H:4]([CH2:34][C:35]1[CH:40]=[CH:39][C:38]([OH:41])=[CH:37][CH:36]=1)[NH:5][C:6](=[O:33])[C@H:7]([CH:30]([CH3:32])[CH3:31])[NH:8][C:9](=[O:29])[C@H:10]([CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:28])[NH2:27])[N:11](C(OC(C)(C)C)=O)[N+:12]([O-:14])=[O:13].[ClH:43]>C(O)(=O)C.O1CCOCC1>[ClH:43].[CH3:1][O:2][C:3](=[O:42])[C@H:4]([CH2:34][C:35]1[CH:40]=[CH:39][C:38]([OH:41])=[CH:37][CH:36]=1)[NH:5][C:6](=[O:33])[C@H:7]([CH:30]([CH3:32])[CH3:31])[NH:8][C:9](=[O:29])[C@H:10]([CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:27])[NH2:28])[NH:11][N+:12]([O-:14])=[O:13]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 178501376HCID 178501376, 화합물

생성물 1

HCID 178501377HCID 178501377, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 312751,4-Dioxane용매

실험 절차

30.9 g of t-butoxycarbonylnitroarginylvalyltyrosine methyl ester is dissolved in 177 ml of acetic acid. To this solution is added 88.5 ml of 6 N hydrochloric acid in dioxane. The reaction is allowed to stand for five minutes and the solvent is removed under vacuum. The residue is triturated with ethyl ether. The resultant precipitate is filtered, washed with ethyl ether and dried in a vacuum oven at 55° C. to afford nitroarginylvalyltyrosine methyl ester hydrochloride.

후처리

  1. customthe solvent is removed under vacuum
  2. customThe residue is triturated with ethyl ether
  3. filtrationThe resultant precipitate is filtered
  4. washwashed with ethyl ether
  5. customdried in a vacuum oven at 55° C.

출처 및 근거

ORD 기록
ord-52b7b15ba7a8458c93963d1ed57909ba
출처 데이터셋
uspto-grants-1980_05
특허 번호
US04204991

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