1-methyl-3-(4-nitro-phenylmethyl)-1H-indole-5-carboxylic acid methyl ester → 3-(4-amino-benzyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester

HRID 1395893

반응식

HRID 1395893 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH3:14])[CH:9]=[C:8]2[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([N+:22]([O-])=O)=[CH:18][CH:17]=1)=[O:4]>[Pd].CO>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH3:14])[CH:9]=[C:8]2[CH2:15][C:16]1[CH:17]=[CH:18][C:19]([NH2:22])=[CH:20][CH:21]=1)=[O:4]

참가 물질

4

반응물 1

HCID 694489971-methyl-3-(4-nitro-phenylmethyl)-1H-indole-5-carboxylic acid methyl ester

생성물 1

HCID 694474993-(4-amino-benzyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester수율 92%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 1-methyl-3-(4-nitro-phenylmethyl)-1H-indole-5-carboxylic acid methyl ester (0.23 g, 0.71 mmol), Pd (10% on carbon, 30 mg) and methanol (5 mL) was stirred under a hydrogen atmosphere (ballon) for 6 hr. The catalyst was removed by filtration and the solvents removed in vacuo to provide of 3-(4-amino-benzyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester (0.19 g, 92% yield).

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvents removed in vacuo

출처 및 근거

ORD 기록
ord-3d587e8d0fa246bc923a358c19c0439b
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08900565B2

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