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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrochloric Acid → (3R,3aR,6R,6aR)-6-(5-fluoro-2-nitro-phenoxy)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol

HRID 1396635
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HRID 1396635 반응식
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH2:12]1[O:16][C@@H:15]2[C@H:17]([OH:20])[CH2:18][O:19][C@@H:14]2[C@@H:13]1[OH:21].[Li+].C[Si]([N-][Si](C)(C)C)(C)C.Cl>C1COCC1>[F:8][C:6]1[CH:5]=[CH:4][C:3]([N+:9]([O-:11])=[O:10])=[C:2]([CH:7]=1)[O:21][C@H:13]1[C@H:14]2[O:19][CH2:18][C@@H:17]([OH:20])[C@H:15]2[O:16][CH2:12]1
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참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 679672,4-DifluoronitrobenzeneHCID 2733832Lithium hexamethyldisilazaneHCID 109756241,4:3,6-Dianhydro-D-mannitol

생성물 1

HCID 86718453(3R,3aR,6R,6aR)-6-(5-fluoro-2-nitro-phenoxy)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매
2회

실험 절차

2.2 ml (20.0 mmol) 2,4-difluoro-1-nitro-benzene and 2.9 g (20.0 mmol) 1,4:3,6-dianhydro-D-mannitol in 70 ml THF are cooled to −5° C. 20 ml (20.0 mml) 1M LiHMDS in THF are added dropwise and the reaction mixture is allowed to warm to RT and stirred over night. 1M HCl is added and the mixture is extracted with EtOAc. The organic phases are pooled and washed with water, dried and evaporated. The residue is purified by FC.

후처리

  1. extractionthe mixture is extracted with EtOAc
  2. washwashed with water
  3. customdried
  4. customevaporated
  5. customThe residue is purified by FC

출처 및 근거

ORD 기록
ord-77e413ac1a06437eace0a97dce5255e0
출처 데이터셋
uspto-grants-2014_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08901138B2

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