1-Methylpiperazine → 2-(4-Methylpiperazin-1-yl)pyrimidin-4-amine
반응식
Cl[C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>CN(C)C=O>[CH3:9][N:10]1[CH2:15][CH2:14][N:13]([C:2]2[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=2)[CH2:12][CH2:11]1참가 물질
4
반응 조건
- 온도
- 220 °C
실험 절차
A mixture of 2-chloro-4-pyrimidinamine (300 mg, 2.316 mmol) and 1-methylpiperazine (771 μl, 6.95 mmol) in N,N-dimethylformamide (DMF) (3 ml) was heated to 220° C. via a microwave reactor for 60 min. The reaction was purified by RP-HPLC to yield 2-(4-methyl-1-piperazinyl)-4-pyrimidinamine (300 mg, 1.552 mmol, 67% yield). MS (ES+) m/z 194.2 (MH+).
후처리
- customThe reaction was purified by RP-HPLC
출처 및 근거
- ORD 기록
- ord-33ad22ccf0de4e249fd27801d60c5e75
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08901119B2
반응 노트
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