Diisopropylethylamine → HCID 68288030, 화합물

HRID 1396909노트

반응식

HRID 1396909 반응식
Cl[C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=1.CCN(C(C)C)C(C)C.[CH3:18][N:19]([CH3:25])[C@H:20]1[CH2:24][CH2:23][NH:22][CH2:21]1>CN(C)C=O>[CH3:18][N:19]([CH3:25])[C@H:20]1[CH2:24][CH2:23][N:22]([C:2]2[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=2)[CH2:21]1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 3457522-Chloro-4-aminopyrimidineHCID 7019156(3S)-(-)-3-(Dimethylamino)pyrrolidine

생성물 1

HCID 68288030HCID 68288030, 화합물수율 64.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
220 °C

실험 절차

A mixture of 2-chloro-4-pyrimidinamine (200 mg, 1.544 mmol), Hunig's base (539 μl, 3.09 mmol) and (3S)—N,N-dimethyl-3-pyrrolidinamine (294 μl, 2.316 mmol) in N,N-dimethylformamide (DMF) (2 ml) was heated to 220° C. via a microwave reactor for 30 min. The reaction mixture was purified by RP-HPLC to yield 2-[(3S)-3-(dimethylamino)-1-pyrrolidinyl]-4-pyrimidinamine (205 mg, 0.989 mmol, 64% yield). MS (ES+) m/z 208.0 (MH+).

후처리

  1. customThe reaction mixture was purified by RP-HPLC

출처 및 근거

ORD 기록
ord-158dd5f833224258a4a06c03d27f9e4d
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901119B2

반응 노트

불러오는 중…