2-Bromo-1-(pyridin-4-yl)ethanone → 2-[4-(Pyridin-4-YL)-1,3-thiazol-2-YL]acetonitrile

HRID 1397236

반응식

HRID 1397236 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)=O.[C:11]([CH2:13][C:14]([NH2:16])=[S:15])#[N:12]>>[N:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:16]=[C:14]([CH2:13][C:11]#[N:12])[S:15][CH:2]=2)=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 4070312-Bromo-1-(pyridin-4-yl)ethanoneHCID 14162772-Cyanoethanethioamide

생성물 1

HCID 247104472-[4-(Pyridin-4-YL)-1,3-thiazol-2-YL]acetonitrile수율 46%

실험 절차

This compound was synthesized from 2-bromo-1-(pyridin-4-yl)ethanone and 2-cyanothioacetamide as described in example 1 step 1 (0.23 g, yield 46%): 1H NMR (300 MHz, MeOD) δ 8.59 (m, 2H), 8.24 (s, 1H), 7.98 (m, 2H), 4.44 (s, 2H). MS (ESI) m/z: Calculated for C10H7N3OS: 201.01. found: 202.2 (M+H)+.

출처 및 근거

ORD 기록
ord-a5d17cc95da94bd18a961cda1451e344
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901156B2

연결된 노트

불러오는 중…