Sodium borohydride → (8-Methyl-2-o-tolylquinolin-3-yl)methanol

HRID 1397655

반응식

HRID 1397655 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH3:18])[C:8]([CH:19]=[O:20])=[CH:7]2.[BH4-].[Na+]>C1COCC1>[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH3:18])[C:8]([CH2:19][OH:20])=[CH:7]2

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 57707895HCID 57707895, 화합물

생성물 1

HCID 57707986(8-Methyl-2-o-tolylquinolin-3-yl)methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Prepared according to Procedure B using 8-methyl-2-o-tolylquinoline-3-carb-aldehyde (1.28 g, 4.9 mmol) and solid NaBH4 (278 mg, 1.5 eq) in THF (10 mL). After purification, (8-methyl-2-o-tolylquinolin-3-yl)methanol was obtained as white solid.

후처리

  1. customPrepared
  2. customAfter purification

출처 및 근거

ORD 기록
ord-3c84b80f0ab1418aae1896c639319c18
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901135B2

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