홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium borohydride → HCID 73292408, 화합물

HRID 1398032
노트
인쇄 미리보기

반응식

HRID 1398032 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13]([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:22])[CH3:21])=[CH:16][CH:15]=2)=[CH:12][C:11]([CH:23]2[CH2:28][C:27]([CH3:30])([CH3:29])[O:26][C:25]([CH3:32])([CH3:31])[CH2:24]2)=[N:10]1.[BH4-].[Na+]>C(O)C.CC#N.C(O)(C(F)(F)F)=O.O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13]([C:14]2[CH:19]=[CH:18][C:17]([CH:20]([OH:22])[CH3:21])=[CH:16][CH:15]=2)=[CH:12][C:11]([CH:23]2[CH2:28][C:27]([CH3:30])([CH3:29])[O:26][C:25]([CH3:31])([CH3:32])[CH2:24]2)=[N:10]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 4311764Sodium borohydrideHCID 73293256HCID 73293256, 화합물

생성물 1

HCID 73292408HCID 73292408, 화합물수율 92%

시약·촉매·용매 3

HCID 702Ethanol용매HCID 6342Acetonitrile용매HCID 22392675Trifluoroacetic acid water용매

실험 절차

To a solution of 1-{4-[1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl]-phenyl}-ethanone (Example 12) (20 mg, 0.05 mmol) in 1 mL of ethanol was added sodium borohydride (1.8 mg, 0.05 mmol) and the mixture stirred for 1 hr at RT. The solution was diluted with 5 mL of 50% CH3CN in 0.1% TFA/H2O and purified by RP-HPLC, eluting with a linear gradient of 50%-100% CH3CN in 0.1% TFA/H2O over 10 mins to give 20 mg (86%) of the title compound a white solid containing 0.5 eq of TFA.

후처리

  1. custompurified by RP-HPLC
  2. washeluting with a linear gradient of 50%-100% CH3CN in 0.1% TFA/H2O over 10 mins

출처 및 근거

ORD 기록
ord-a5124f3b6d564495bc7d3802dd30e69c
출처 데이터셋
uspto-grants-2014_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08901314B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트