Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-Alanine → (S)-2-(2,4-dinitrobenzamido)propanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-Alanine | HCID 5950 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Benzoic acid, 2,6-dinitro- | HCID 119206 | — |
| 용매 | 2,4-Dinitrobenzoyl chloride | HCID 88401 | — |
| 생성물 | (S)-2-(2,4-dinitrobenzamido)propanoic acid | HCID 86713104 | — |
반응 단계
The reaction of 2,4-dinitrobenzoyl chloride (prepared from 2,4-dinitrobenzoic acid, 2 g and SOCl2, 20 mL) with L-alanine (1.04 g, 11.79 mmol) in the presence of Na2CO3 (1.24 g, 11.79 mmol) as described in intermediate 2 gave the title compound as an off-white color solid (2.08 g, 78%), mp 194-196° C. 1H NMR (400 MHz, DMSO-d6): δ 12.77 (1H, s), 9.25 (1H, d, J=7.6 Hz), 8.77 (1H, d, J=2.0 Hz), 8.63 (1H, dd, J=8.4, 2.0 Hz), 7.87 (1H, d, J=8.4 Hz), 4.44 (1H, pentet, J=7.3 Hz), 1.38 (3H, d, J=7.2 Hz); LC-MS (negative ion mode): m/z 282 (M−H)−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08906344B2 |
| 출처 데이터셋 | uspto-grants-2014_12 |
| ORD ID | ord-00e1b45795124920bf4c88c1e0afe130 |
| 출처 메모 | uspto-grants-2014_12 |