Sodium Hydroxide → 2-(4-Methyl-2,6-dip-tolylpyrimidin-5-yl)pentanoic acid

HRID 1399581노트

반응식

HRID 1399581 반응식
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11]C)=[O:10])=[C:6]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)[N:5]=[C:4]([C:23]2[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=[O:10])=[C:6]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)[N:5]=[C:4]([C:23]2[CH:24]=[CH:25][C:26]([CH3:29])=[CH:27][CH:28]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 66955816Methyl 2-(4-methyl-2,6-dip-tolylpyrimidin-5-yl)pentanoate

생성물 1

HCID 669559252-(4-Methyl-2,6-dip-tolylpyrimidin-5-yl)pentanoic acid

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
100 °C

실험 절차

To a solution of methyl 2-(4-methyl-2,6-dip-tolylpyrimidin-5-yl)pentanoate (86 mg; 0.221 mmol) in methanol (2.214 ml) was added a 10 N sodium hydroxide solution (221 μl; 2.21 mmol) and the mixture was heated at 100° C. overnight. The volatiles were removed under reduced pressure and the mixture was acidified by adding 6N hydrochloric acid. The suspension was extracted twice with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulphate and concentrated under reduced pressure.

후처리

  1. customThe volatiles were removed under reduced pressure
  2. additionby adding 6N hydrochloric acid
  3. extractionThe suspension was extracted twice with ethyl acetate
  4. washThe combined organic layers were washed with brine
  5. dry with materialdried over magnesium sulphate
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f6131ff8e4cf4dc79d3051a42ce566a2
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906906B2

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