Hydrochloric Acid → HCID 12394366, 화합물

HRID 1399939

반응식

HRID 1399939 반응식
[N+:1]([C:4]1[CH:5]=[C:6](/[CH:10]=[CH:11]/[C:12]([O:14][CH3:15])=[O:13])[CH:7]=[CH:8][CH:9]=1)([O-])=O.Cl>CCO.[Fe]>[NH2:1][C:4]1[CH:5]=[C:6](/[CH:10]=[CH:11]/[C:12]([O:14][CH3:15])=[O:13])[CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 5354136Methyl (2E)-3-(3-nitrophenyl)-2-propenoate

생성물 1

HCID 12394366HCID 12394366, 화합물수율 57%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 702Ethanol용매

실험 절차

A solution of (E)-methyl 3-(3-nitrophenyl)acrylate (20.14 g, 0.097 mol), Fe (32.5 g, 0.58 mol), concentrated HCl (3.5 ml) in 50% EtOH (100 ml) was refluxed for 2 h. Upon completion, the solution was filtered through Celite and washed with EtOH. The filtrate was concentrated and extracted with dichloromethane. The combined organic phase was dried over MgSO4 and concentrated to afford (E)-methyl 3-(3-aminophenyl)acrylate as a yellow solid (9.73 g, 57%).

후처리

  1. filtrationUpon completion, the solution was filtered through Celite
  2. washwashed with EtOH
  3. concentrationThe filtrate was concentrated
  4. extractionextracted with dichloromethane
  5. dry with materialThe combined organic phase was dried over MgSO4
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c4c6ac0849a543009493f1c2594735b1
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906909B2

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