Sodium Hydroxide → 2-(Benzo[d]oxazol-2-yl)nicotinic acid

HRID 1400237노트

반응식

HRID 1400237 반응식
[OH-].[Na+].[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[N:5]=[C:4]1[C:12]1[N:22]=[CH:21][CH:20]=[CH:19][C:13]=1[C:14]([O:16]CC)=[O:15]>CCO>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[N:5]=[C:4]1[C:12]1[N:22]=[CH:21][CH:20]=[CH:19][C:13]=1[C:14]([OH:16])=[O:15]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 67540260Ethyl 2-(benzo[d]oxazol-2-yl)nicotinate

생성물 1

HCID 675405322-(Benzo[d]oxazol-2-yl)nicotinic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

NaOH (1.65 mL, 2M in water) was added to a solution of ethyl 2-(benzo[d]oxazol-2-yl)nicotinate (290 mg, 0.973 mmol) in EtOH. After stirring for 3 h at room temperature the solvent was removed in vacuo. The residue was dissolved in water (4 mL) and dilute HCl (1.8 mL, 2M in water) was added resulting in pH 2-3 of the mixture. The mixture was extracted with dichloromethane. The combined organic layers were washed with saturated aqueous NaCl solution and dried over MgSO4. Removal of the solvent provided the title compound (190 mg, 81%); ESI-MS [M+H+]=241.1.

후처리

  1. customwas removed in vacuo
  2. dissolutionThe residue was dissolved in water (4 mL)
  3. additiondilute HCl (1.8 mL, 2M in water) was added

출처 및 근거

ORD 기록
ord-5ae51abd7b2042dfaa112115988f8ffd
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906941B2

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