Sodium Hydroxide → 2-(2-Phenyloxazol-4-yl)nicotinic acid

HRID 1400240노트

반응식

HRID 1400240 반응식
[OH-].[Na+].[C:3]1([C:9]2[O:10][CH:11]=[C:12]([C:14]3[N:24]=[CH:23][CH:22]=[CH:21][C:15]=3[C:16]([O:18]CC)=[O:17])[N:13]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CCO>[C:3]1([C:9]2[O:10][CH:11]=[C:12]([C:14]3[N:24]=[CH:23][CH:22]=[CH:21][C:15]=3[C:16]([OH:18])=[O:17])[N:13]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 67540589Ethyl 2-(2-phenyloxazol-4-yl)nicotinate

생성물 1

HCID 675401952-(2-Phenyloxazol-4-yl)nicotinic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

An aqueous solution of NaOH (0.27 mL, 2M in water, 0.54 mmol) was added to a solution of ethyl 2-(2-phenyloxazol-4-yl)nicotinate (80 mg, 0.27 mmol) in EtOH (2.7 mL). After stirring overnight at room temperature the solvent was removed in vacuo, the residue was dissolved in water and HCl (2M in water) was added until pH ˜1 was obtained. The solvent was removed in vacuo and the crude product obtained was used without further purification; ESI-MS [M+H+]=267.1.

후처리

  1. customwas removed in vacuo
  2. dissolutionthe residue was dissolved in water
  3. additionHCl (2M in water) was added until pH ˜1
  4. customwas obtained
  5. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-61af3a1a91dc4ddaba4b262e17fdf8cc
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906941B2

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