HCID 86709753, 화합물 → HCID 68152103, 화합물
반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:12][CH2:13][CH2:14][NH:15]C(=O)OC(C)(C)C>C(OCC)C.Cl.O1CCOCC1>[Cl-:1].[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:12][CH2:13][CH2:14][NH3+:15]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
To a cooled (0° C.) single necked flask containing a solution of tert-butyl {2-[(1-chloronaphthalen-2-yl)amino]ethyl}carbamate in 4 mL of ethyl ether, 5 mL of 4 M HCl solution in dioxane were added. The resulting mixture was stirred at room temperature for 7 h. The reaction mixture was concentrated under reduce pressure to afford 2-[(1-chloronaphthalen-2-yl)amino]ethanaminium chloride as a pink solid (92% yield) which was pure by TLC and NMR analysis.
후처리
- additionwere added
- concentrationThe reaction mixture was concentrated
출처 및 근거
- ORD 기록
- ord-95b35fc76b3f4997b474a1a7b1b3ded9
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08906946B2
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