Hydrochloric Acid → HCID 68151396, 화합물

HRID 1400293노트

반응식

HRID 1400293 반응식
[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:12][CH2:13][CH2:14][NH:15]C(=O)OC(C)(C)C.[ClH:23]>C(OCC)C.O1CCOCC1>[Cl-:23].[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:12][CH2:13][CH2:14][NH3+:15]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 86709754HCID 86709754, 화합물

생성물 1

HCID 68151396HCID 68151396, 화합물수율 95%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 312751,4-Dioxane용매

반응 조건

온도
0 °C

실험 절차

To a cooled (0° C.) single necked flask containing a solution of tert-butyl {2-[(1-fluoronaphthalen-2-yl)oxy]ethyl}carbamate in 5 mL of ethyl ether, 5 mL of 4 M HCl solution in dioxane were added. The resulting mixture was stirred at room temperature for 18 h. The reaction mixture was concentrated under reduce pressure to afford 2-[(1-fluoronaphthalen-2-yl)oxy]ethanaminium chloride as a white solid (95% yield) which was pure by TLC and NMR analysis.

후처리

  1. additionwere added
  2. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-eca7b5b7cf784964883089e8fdc6d479
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906946B2

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