Diisopropylethylamine → HCID 86711436, 화합물

HRID 1401093노트

반응식

HRID 1401093 반응식
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH:17]([CH3:19])[CH3:18])[CH:15]=2)[C:10]([CH:20]=[CH:21][C:22](O)=[O:23])=[CH:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:25][C:26]1[CH:27]=[C:28]([CH:36]=[CH:37][CH:38]=1)[C:29]([NH:31][NH:32][CH:33]([CH3:35])[CH3:34])=[O:30].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(CC)C(C)C)(C)C>CN(C=O)C.CCOC(C)=O>[F:25][C:26]1[CH:27]=[C:28]([CH:36]=[CH:37][CH:38]=1)[C:29]([NH:31][N:32]([C:22](=[O:23])/[CH:21]=[CH:20]/[C:10]1[C:11]2[C:16](=[CH:15][C:14]([CH:17]([CH3:18])[CH3:19])=[CH:13][CH:12]=2)[N:8]([C:6]([O:5][C:1]([CH3:3])([CH3:2])[CH3:4])=[O:7])[CH:9]=1)[CH:33]([CH3:35])[CH3:34])=[O:30]

참가 물질

7

반응물 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 86711429HCID 86711429, 화합물HCID 86711437HCID 86711437, 화합물

생성물 1

HCID 86711436HCID 86711436, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To solution containing 3-(1-(tert-butoxycarbonyl)-6-isopropyl-1H-indol-3-yl)acrylic acid (183.0 mg, 0.56 mmol), 3-fluoro-N′-isopropylbenzohydrazide (163.5 mg, 0.83 mmol) and HATU (316.9 mg, 0.83 mmol) dissolved in DMF (3.0 ml), N,N-diisopropylethylamine (DIPEA)(0.14 ml, 0.83 mmol) was slowly drop-wise added and stirred at room temperature for 12 hr. The reaction mixture was diluted with EtOAc, washed with water and brine, dried with anhydrous MgSO4, filtered, and concentrated under reduced pressure. The residue was separated through silica gel chromatography (33% EtOAc) for refinement, and dried so that white (E)-tert-butyl 3-(3-(2-(3-fluorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-5-methyl-1H-indole-1-carboxylate was obtained (138.0 mg, 48.6%).

후처리

  1. washwashed with water and brine
  2. dry with materialdried with anhydrous MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was separated through silica gel chromatography (33% EtOAc) for refinement
  6. dry with materialdried so that white (E)-tert-butyl 3-(3-(2-(3-fluorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-5-methyl-1H-indole-1-carboxylate
  7. customwas obtained (138.0 mg, 48.6%)

출처 및 근거

ORD 기록
ord-aaa016416fc4404bba223432a4e1c8f0
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906952B2

반응 노트

불러오는 중…