Dimethylformamide dimethyl acetal → HCID 178484325, 화합물

HRID 1401249노트

반응식

HRID 1401249 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([NH2:10])=[O:9])=[N:6][CH:7]=1.CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](/[N:10]=[CH:13]/[N:14]([CH3:16])[CH3:15])=[O:9])=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 7351515-Bromopyridine-2-carboxamide

생성물 1

HCID 178484325HCID 178484325, 화합물수율 95%

실험 절차

A solution of 5-bromopicolinamide (0.500 g, 2.49 mmol) and dimethylformamide dimethylacetal (20 mL), were heated to 85° C. for 3 h. The reaction was concentrated and the product was used directly in the next step (0.604 g, 95% yield). MS (ESI) m/z 257.1 [M+1]+.

후처리

  1. concentrationThe reaction was concentrated

출처 및 근거

ORD 기록
ord-a7dbfe3a6e8c46afa533541b082caea3
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08907087B2

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