Hydrochloric Acid → 5-[3,4-Bis(benzyloxy)-5-nitrophenyl]-2H-tetrazole

HRID 1401303노트

반응식

HRID 1401303 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([N+:25]([O-:27])=[O:26])[C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:12]#[N:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N-:28]=[N+:29]=[N-:30].[Na+].[Cl-].[NH4+].Cl>CN(C)C=O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:12]2[N:28]=[N:29][NH:30][N:13]=2)[CH:14]=[C:15]([N+:25]([O-:27])=[O:26])[C:16]=1[O:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 670369943,4-Bis(benzyloxy)-5-nitrobenzonitrile

생성물 1

HCID 670370545-[3,4-Bis(benzyloxy)-5-nitrophenyl]-2H-tetrazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
85 °C

실험 절차

A mixture of 3,4-bis-benzyloxy-5-nitro-benzonitrile (0.54 g, 1.50 mmol), sodium azide (0.15 g, 2.25 mmol) and ammonium chloride (0.12 g, 2.25 mmol) in dimethylformamide (3 mL) was stirred at 85° C. for 20 hours. After cooling to room temperature, the reaction mixture was poured onto water (30 mL) and acidified with dilute hydrochloric acid. The resulting precipitate was collected, washed with water and dried to yield 5-(3,4-bis-benzyloxy-5-nitro-phenyl)-2H-tetrazole, 0.53 g (87%).

후처리

  1. temperatureAfter cooling to room temperature
  2. additionthe reaction mixture was poured onto water (30 mL)
  3. customThe resulting precipitate was collected
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-ad81b7da7ebe4a17b9cb9f2e7ae90a9e
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08907099B2

반응 노트

불러오는 중…