Hydrochloric Acid → HCID 67324366, 화합물

HRID 1401784노트

반응식

HRID 1401784 반응식
[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][CH:22]([NH2:25])[CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2.C(OC([N:34]1[CH2:38][CH2:37][C@H:36]([OH:39])[C@H:35]1[C:40](O)=[O:41])=O)(C)(C)C.Cl>O1CCOCC1>[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][CH:22]([NH:25][C:40]([C@@H:35]5[C@@H:36]([OH:39])[CH2:37][CH2:38][NH:34]5)=[O:41])[CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14037017(2S,3S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acidHCID 53312200HCID 53312200, 화합물

생성물 1

HCID 67324366HCID 67324366, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

The preparation was carried out analogously starting from 244 mg (0.50 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamine and 116 mg (0.50 mmol) of (2S,3S)-3-hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester. The protecting group was cleaved off analogously using HCl in dioxane. The product was purified by means of flash chromatography on silica gel.

후처리

  1. customThe product was purified by means of flash chromatography on silica gel

출처 및 근거

ORD 기록
ord-ddc62276da474bd4bbad61cf84768d28
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08907098B2

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