Hydrochloric Acid → (S)-2-amino-3-hydroxy-N-{2-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]ethyl}propionamide

HRID 1401866노트

반응식

HRID 1401866 반응식
Cl.C(OC(=O)[NH:8][C@H:9]([C:12](=[O:35])[NH:13][CH2:14][CH2:15][C:16]1[S:17][CH:18]=[C:19]([C:21]2[CH:30]=[CH:29][C:28]3[C:27]([CH3:32])([CH3:31])[CH2:26][CH2:25][C:24]([CH3:34])([CH3:33])[C:23]=3[CH:22]=2)[N:20]=1)[CH2:10][OH:11])(C)(C)C>O1CCOCC1>[NH2:8][C@@H:9]([CH2:10][OH:11])[C:12]([NH:13][CH2:14][CH2:15][C:16]1[S:17][CH:18]=[C:19]([C:21]2[CH:30]=[CH:29][C:28]3[C:27]([CH3:32])([CH3:31])[CH2:26][CH2:25][C:24]([CH3:34])([CH3:33])[C:23]=3[CH:22]=2)[N:20]=1)=[O:35]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67324809((S)-2-hydroxy-1-{2-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]ethylcarbamoyl}ethyl)carbamic acid tert-butyl ester

생성물 1

HCID 67322250(S)-2-amino-3-hydroxy-N-{2-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]ethyl}propionamide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

The protecting group is cleaved off as already described using HCl in dioxane starting from 82 mg (0.16 mmol) of ((S)-2-hydroxy-1-{2-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]ethylcarbamoyl}ethyl)carbamic acid tert-butyl ester from step c. The product is purified by means of preparative HPLC and is in the form of the formate.

후처리

  1. customThe product is purified by means of preparative HPLC

출처 및 근거

ORD 기록
ord-b8317bcc5a754a2589d1ad8df4e5e953
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08907098B2

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