Hydrochloric Acid → HCID 25129245, 화합물

HRID 1402684노트

반응식

HRID 1402684 반응식
[OH:1][C@H:2]([C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=1)[C@H:3]([NH:10][C:11](=[O:20])OCC1C=CC=CC=1)[CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.[CH3:30][CH2:31][OH:32]>[Pd]>[OH:1][C@H:2]([C:21]1[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=1)[C@H:3]([NH:10][C:11](=[O:20])[CH2:30][CH2:31][O:32][C:24]1[CH:25]=[CH:26][C:21]([CH3:2])=[CH:22][CH:23]=1)[CH2:4][N:5]1[CH2:6][CH2:7][CH2:8][CH2:9]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 59531008HCID 59531008, 화합물

생성물 1

HCID 25129245HCID 25129245, 화합물수율 85%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

A mixture of benzyl(1R,2R)-1-hydroxy-1-(4-methoxyphenyl)-3-(pyrrolidin-1-yl)propan-2-ylcarbamate (0.10 g, 0.26 mmol) and Pd/C (5%, 21 mg) in EtOH (1 mL)/HCl (1 M, 50 μL) was degassed and hydrogen gas was added. The mixture was hydrogenated at atmospheric pressure for two hours. The mixture was filtered over celite and the solvent was removed to dryness. The product was obtained as a colorless oil (63.5 mg, 85% yield).

후처리

  1. customwas degassed
  2. additionhydrogen gas was added
  3. filtrationThe mixture was filtered over celite
  4. customthe solvent was removed to dryness

출처 및 근거

ORD 기록
ord-80a6d3c15e304df08e207dfa9f0bc1f2
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08912177B2

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