Sodium Hydroxide → (6-Methylpyridin-3-yl)acetic acid
반응식
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1참가 물질
4
반응 조건
- 온도
- 65 °C
실험 절차
To a stirred solution of methyl (6-methylpyridin-3-yl)acetate (60 mg, 0.36 mmol) in methanol (5 ml) was added NaOH (1.0 ml of a 2M aqueous solution, 2.0 mmol) and the resulting solution was heated at 65° C. for 2 hours. The solvent was then removed at reduced pressure and the resulting residue was dissolved in methanolic HCl (5 ml) and then reconcentrated to yield the title product (54 mg, quant. yield) that was used without further purification.
후처리
- customThe solvent was then removed at reduced pressure
- dissolutionthe resulting residue was dissolved in methanolic HCl (5 ml)
출처 및 근거
- ORD 기록
- ord-c3ba509f4e4840ceab22ea9d201ac51e
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08912176B2
반응 노트
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