Bromine → 5-bromo-7H-pyrrolo[2,3-d]pyrimidine
반응식
[N:1]1[C:6]2[NH:7][CH:8]=[CH:9][C:5]=2[CH:4]=[N:3][CH:2]=1.[Br:10]Br>C(Cl)(Cl)Cl.C(Cl)(Cl)(Cl)Cl>[Br:10][C:9]1[C:5]2[CH:4]=[N:3][CH:2]=[N:1][C:6]=2[NH:7][CH:8]=1참가 물질
5
실험 절차
5-Bromo-7H-pyrrolo[2,3-d]pyrimidine (7) is prepared by dissolving 7H-pyrrolo[2,3-d]pyrimidine (6) in chloroform and slowly adding Br2 in carbon tetrachloride at 0° C. After stirring for 1-2 hours, the reaction may be quenched in aqueous hydrochloric acid. Isolation by conventional means (e.g. extraction and silica gel chromatography) provides compound 7.
후처리
- custom5-Bromo-7H-pyrrolo[2,3-d]pyrimidine (7) is prepared
- customthe reaction
- custommay be quenched in aqueous hydrochloric acid
- extractionIsolation by conventional means (e.g. extraction and silica gel chromatography)
출처 및 근거
- ORD 기록
- ord-524cbe2d29854b478a60fad5a21d2026
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08912204B2
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