HCID 13013041, 화합물 → 3(2H)-Benzofuranone, 6-methyl-

HRID 1403374노트

반응식

HRID 1403374 반응식
C([O:4][C:5]1[C:9]2[CH:10]=[CH:11][C:12]([CH3:14])=[CH:13][C:8]=2[O:7][CH:6]=1)(=O)C>Cl.CO.O>[CH3:14][C:12]1[CH:11]=[CH:10][C:9]2[C:5](=[O:4])[CH2:6][O:7][C:8]=2[CH:13]=1

참가 물질

5

반응물 1

HCID 13013041HCID 13013041, 화합물

생성물 1

HCID 303493(2H)-Benzofuranone, 6-methyl-수율 84.5%

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 887Methanol용매HCID 962Water용매2회

실험 절차

A solution of 6-methyl-1-benzofuran-3-yl acetate (3.8 g, 19.98 mmol) in HCl (4 mL, conc), methanol (160 mL), and water (40 mL) was heated under reflux for 1.5 h, the reaction mixture was cooled to room temperature, dissolved in water (200 mL) and filtered to give 6-methyl-2,3-dihydro-1-benzofuran-3-one as a white solid (2.5 g, 82%).

후처리

  1. temperatureunder reflux for 1.5 h
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-75f79bb0ab40469d8f7456c064634fd3
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08912188B2

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