Water → HCID 178461408, 화합물

HRID 1403529노트

반응식

HRID 1403529 반응식
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:19]([N:20]4[CH2:24][CH2:23][CH2:22][C@@H:21]4[CH3:25])=[N:18][C:17]4[C:12](=[CH:13][CH:14]=[C:15]([C:26]([O:28]C)=[O:27])[CH:16]=4)[N:11]=3)=[CH:9][C:4]=2[N:3]=[N:2]1.[OH-].[Na+].O>CO>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:19]([N:20]4[CH2:24][CH2:23][CH2:22][C@@H:21]4[CH3:25])=[N:18][C:17]4[C:12](=[CH:13][CH:14]=[C:15]([C:26]([OH:28])=[O:27])[CH:16]=4)[N:11]=3)=[CH:9][C:4]=2[N:3]=[N:2]1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 178497313HCID 178497313, 화합물

생성물 1

HCID 178461408HCID 178461408, 화합물수율 73.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of (S)-methyl 2-(1H-benzo[d][1,2,3]triazol-5-yl)-3-(2-methylpyrrolidin-1-yl)quinoxaline-6-carboxylate (130 mg, 0.33 mmol) in methanol (30 mL) was added sodium hydroxide (40.2 mg, 1.00 mmol) and water (1 mL) with stirring for overnight at room temperature. The resulting mixture was concentrated under vacuum and dissolved in water (25 mL), and adjusted to pH 4 with HCl (3N) to give the precipitate, which was collected by filtration to afford (S)-2-(1H-benzo[d][1,2,3]triazol-5-yl)-3-(2-methylpyrrolidin-1-yl)quinoxaline-6-carboxylic acid as a yellow solid (90.3 mg, 72%).

후처리

  1. concentrationThe resulting mixture was concentrated under vacuum
  2. dissolutiondissolved in water (25 mL)
  3. customto give the precipitate, which
  4. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-a110521f8b8d436a9154b3adfaefb9b8
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08912188B2

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