Phenol → Phenyl 1H-imidazole-1-sulfonate

HRID 1403722노트

반응식

HRID 1403722 반응식
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:8](N1C=CN=C1)([N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1)(=[O:10])=[O:9].C([O-])([O-])=O.[Cs+].[Cs+]>C1COCC1>[N:11]1([S:8]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:10])=[O:9])[CH:15]=[CH:14][N:13]=[CH:12]1

참가 물질

5

반응물 3

HCID 996PhenolHCID 10796Cesium carbonateHCID 816091,1'-sulphonylbis-1H-imidazole

생성물 1

HCID 90409877Phenyl 1H-imidazole-1-sulfonate수율 60.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of phenol (400 mg, 4.3 mmol) in THF (25 mL) was added 1,1′-sulfonyldiimidazole (1.0 g, 5.1 mmol) and Cs2CO3 (2.8 g, 8.5 mmol). The mixture was stirred at ambient temperature for 16 h. The solvent was removed and the residue was purified by silica gel chromatography to yield the title compound (580 mg, 60%).

후처리

  1. customThe solvent was removed
  2. customthe residue was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-3d58a4fabebf41b3a136f564eca7e95a
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08912219B2

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