Triethylamine → (1-Benzyl-1H-indazol-5-yl)-(6-bromoquinazolin-4-yl)amine

HRID 1403765

반응식

HRID 1403765 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2Cl.[NH2:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[N:19]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[N:18]=[CH:17]2.C(N(CC)CC)C>C(#N)C.C(OCC)(=O)C.O>[CH2:23]([N:19]1[C:20]2[C:16](=[CH:15][C:14]([NH:13][C:5]3[C:4]4[C:9](=[CH:10][CH:11]=[C:2]([Br:1])[CH:3]=4)[N:8]=[CH:7][N:6]=3)=[CH:22][CH:21]=2)[CH:17]=[N:18]1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

참가 물질

7

반응물 3

HCID 8471TriethylamineHCID 2120691-(Phenylmethyl)-1H-indazol-5-amineHCID 167703106-Bromo-4-chloro-quinazoline

생성물 1

HCID 21951963(1-Benzyl-1H-indazol-5-yl)-(6-bromoquinazolin-4-yl)amine수율 83.4%

시약·촉매·용매 3

HCID 962Water용매HCID 6342Acetonitrile용매HCID 8857Ethyl Acetate용매

실험 절차

Prepared according to Procedure A from 6-bromo-4-chloroquinazoline (5.0 g) and 5-amino-1-benzyl-1H-indazole (5.0 g) in acetonitrile (100 ml) at 100° C. The resulting precipitate was treated with triethylamine in ethyl acetate and water to give the title compound as a yellow solid, (7.37 g); δ H [2H6]-DMSO 9.93 (1H, s), 8.82 (1H, d), 8.52 (1H, s), 8.19 (1H, s), 8.09 (1H, s), 7.92 (1H, dd), 7.65 (3H, m), 7.25 (5H, m), 5.62 (2H, s).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-abe543ad5d7b487abb4a667907be23bc
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08912205B2

연결된 노트

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