Hydrochloric Acid → (1R)-1-(4-bromo-2-fluorophenyl)ethan-1-amine hydrochloride
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[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([NH:10][S@](C(C)(C)C)=O)[CH3:9])=[C:4]([F:17])[CH:3]=1.[ClH:18].O1CCOCC1>CO>[ClH:18].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([NH2:10])[CH3:9])=[C:4]([F:17])[CH:3]=1참가 물질
5
실험 절차
To a solution of (S)-2-methyl-propane-2-sulfinic acid [(R)-1-(4-bromo-2-fluoro-phenyl)-ethyl]-amide (4.02 g, 12.5 mmol) in methanol (25 ml) was added a 4M HCl solution in dioxane (6.24 ml, 25.0 mmol) and the mixture was stirred for 4 h. The reaction mixture was then concentrated and diethyl ether was added. The resulting suspension was stirred for 2 h and then filtered to deliver the title compound as white solid (3.11 g, 98%).
후처리
- concentrationThe reaction mixture was then concentrated
- additiondiethyl ether was added
- stirringThe resulting suspension was stirred for 2 h
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-c4adba9c5cd344a48c00c3e4a5cae258
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08912221B2
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