Hydrochloric Acid → N-benzyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1H-pyrrolo[3,2-b]pyridin-1-amine

HRID 1404612노트

반응식

HRID 1404612 반응식
[CH2:1]([NH:8][N:9]1[C:17]2[C:12](=[N:13][CH:14]=[C:15]([C:18]3[CH:19]=[N:20][N:21]([CH:23]4[CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH2:24]4)[CH:22]=3)[CH:16]=2)[CH:11]=[CH:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>CO>[CH2:1]([NH:8][N:9]1[C:17]2[C:12](=[N:13][CH:14]=[C:15]([C:18]3[CH:19]=[N:20][N:21]([CH:23]4[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]4)[CH:22]=3)[CH:16]=2)[CH:11]=[CH:10]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67458095tert-butyl 4-{4-[1-(benzylamino)-1H-pyrrolo[3,2-b]pyridin-6-yl]-1H-pyrazol-1-yl}piperidine-1-carboxylate

생성물 1

HCID 58532480N-benzyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1H-pyrrolo[3,2-b]pyridin-1-amine수율 51%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of tert-butyl 4-{4-[1-(benzylamino)-1H-pyrrolo[3,2-b]pyridin-6-yl]-1H-pyrazol-1-yl}piperidine-1-carboxylate (25 mg, 0.053 mmol) in MeOH (0.3 mL) was treated with HCl (4.0M solution in dioxane, 1.5 mL) at room temperature for 30 min. Solvents were evaporated and the residue was diluted with aq. NaHCO3, extracted with ethyl acetate. The organic layer was dried, filtered and evaporated to give a white solid (10 mg, yield 51%).

후처리

  1. customSolvents were evaporated
  2. additionthe residue was diluted with aq. NaHCO3
  3. extractionextracted with ethyl acetate
  4. customThe organic layer was dried
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-3791328c92394789b4478d2ac7a26b14
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08912330B2

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