Hydrochloric Acid → 2-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-1-(4-hydroxy-phenyl)-propan-1-one hydrochloride

HRID 1404694노트

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HRID 1404694 반응식
[CH2:1]([N:8]([CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:24][CH:23]=1)[CH:9]([CH3:19])[C:10]([C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:36]>CC(=O)CC>[ClH:36].[CH2:1]([N:8]([CH2:20][CH2:21][C:22]1[CH:23]=[CH:24][C:25]([O:28][CH2:29][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)=[CH:26][CH:27]=1)[CH:9]([CH3:19])[C:10]([C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 545759581-(4-Hydroxyphenyl)-2-[[2-[4-(phenylmethoxy)phenyl]ethyl](phenylmethyl)amino]-1-propanone

생성물 1

HCID 545759592-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-1-(4-hydroxy-phenyl)-propan-1-one hydrochloride수율 95%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매2회

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온도
50 °C

실험 절차

20 g of 2-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-1-(4-hydroxy-phenyl)-propan-1-one and 100 ml of methyl ethyl ketone are introduced into a 250 ml reactor. At 20° C., 9 g of a solution with 19% by weight of HCl in 2-butanone are added. Once the precipitation of the solid has occurred, it is heated to 50° C. and it is diluted with 40 ml of methyl ethyl ketone. It is kept under stirring for an hour and then it is cooled down again to 20° C. The solid is filtered and is washed with 80 ml of methyl ethyl ketone. After vacuum drying at 40° C., 20.6 g of 2-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-1-(4-hydroxy-phenyl)-propan-1-one hydrochloride as a white solid, are obtained.

후처리

  1. customOnce the precipitation of the solid
  2. additionit is diluted with 40 ml of methyl ethyl ketone
  3. temperatureit is cooled down again to 20° C
  4. filtrationThe solid is filtered
  5. washis washed with 80 ml of methyl ethyl ketone
  6. customAfter vacuum drying at 40° C.

출처 및 근거

ORD 기록
ord-72070bf322064cbb978e0405d910afe4
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08912360B2

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