Water → 2-(5-Fluorobenzofuran-2-yl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid

HRID 1405321노트

반응식

HRID 1405321 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[C:19]([N:20]([CH:22]([CH3:24])[CH3:23])[CH3:21])=[N:18][C:17]4[C:12](=[CH:13][CH:14]=[C:15]([C:25]([O:27]C)=[O:26])[CH:16]=4)[N:11]=3)=[CH:7][C:6]=2[CH:29]=1.[OH-].[Na+].O>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[C:19]([N:20]([CH:22]([CH3:24])[CH3:23])[CH3:21])=[N:18][C:17]4[C:12](=[CH:13][CH:14]=[C:15]([C:25]([OH:27])=[O:26])[CH:16]=4)[N:11]=3)=[CH:7][C:6]=2[CH:29]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 70654230Methyl 2-(5-fluorobenzofuran-2-yl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylate

생성물 1

HCID 509916632-(5-Fluorobenzofuran-2-yl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid수율 90.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of methyl 2-(5-fluorobenzofuran-2-yl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylate (560 mg, 1.42 mmol) in methanol (30 ml) was added sodium hydroxide (227.9 mg, 5.69 mmol) and water (2 ml) with stirring overnight at room temperature. The reaction mixture was concentrated in vacuo and dissolved in water (30 ml), adjusted to pH 5 with HCl (3N). The product was precipitated from water and collected by filtration to afford 2-(5-fluorobenzofuran-2-yl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid as a light yellow solid (486 mg, 90%).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. dissolutiondissolved in water (30 ml)
  3. customThe product was precipitated from water
  4. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-d38286950eb3488dba9eb77c6c8c6577
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916561B2

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